�
New findings published in the August 27 issue of JAMA
call into interrogative sentence the tight glucose control that many professional
societies recommend for critically inauspicious adults. Researchers performed a
meta-analysis and found that tight glucose control is not associated
with a significant step-down in risk of end in the hospital, merely it
is linked to an increased risk of hypoglycemia (lour than normal
glucose sugar levels).
A randomised controlled test published in 2001 by van den Berghe et al found a 33% reduction in risk of hospital mortality for critically ill
operative patients world Health Organization practiced soaked glucose control. "Because few
interventions in critically ill adult patients reduce mortality to this
extent, the results of this trial were sky-high received and
rapidly incorporated into guidelines," write Renda Soylemez
Wiener, M.D., M.P.H., (Department of Veterans
Affairs Medical Center, White River Junction, Vt., and Dartmouth
Medical School, Hanover, N.H.) and colleagues.
Further, tight glucose control in all critically ill patients is a
recommendation of highly well-thought-of organization such as the American
Diabetes Association and the American Association of Clinical
Endocrinologists. "These recommendations have light-emitting diode to worldwide adoption
of tight glucose control in a variety of intensive care unit (ICU)
settings," according to Wiener. However, on that point are some trials of tight
glucose control in certain intensive care unit (ICU) settings that have
not resulted in mortality benefit merely have resulted in an increased
risk of infection for hypoglycemia.
In the meta-analysis, Wiener and colleagues studied 29 randomized
controlled trials with 8,432 patients that compared risks and benefits
of usual upkeep in critically ill adults with tight glucose control
(glucose goal of less than 150 mg/dL).
One finding was that 'tween tight glucose control and usual forethought
strategies, thither was no significant conflict in infirmary mortality -
21.6% to 23.3%, severally. The researchers also noted no significant
differences in hospital mortality when separately analyzing surgical,
medical, and medical-surgical ICU settings. While tight glucose control
resulted in a risk of new need for dialysis by 11.2%, the rate for
usual charge was 12.1% - not a significant difference of opinion. However, tight
glucose control condition was associated with a significantly decreased risk of
septicemia, a generalized malady due to bacteria in the blood stream
(10.9% to 13.4%, severally). Additionally, the risk of hypoglycemia
under tight glucose control was about 5 times higher than under usual
care (13.7% to 2.5%).
The authors reason out that, "Given the overall findings of this
meta-analysis, it seems appropriate that the guidelines recommending
tight glucose control in all critically ill patients should be
re-evaluated until the results of larger, more definitive clinical
trials ar available."
Simon Finfer, M.B.B.S., F.J.F.I.C.M. (The George Institute for
International Health) and Anthony Delaney, M.B.B.S., F.J.F.I.C.M.
(Royal North Shore Hospital, Sydney, Australia) write in an
accompanying comment that:
"Possible explanations for the discordant results of the study by van
den Berghe et al and the meta-analysis by Wiener et al are that the
meta-analysis is flawed, the studies that strain the ground of the
meta-analysis ar flawed or inherently different, or the findings of
the study by van den Berghe et al occurred ascribable to random chance or as a
result of another unique factor interacting with tight glycemic
control."
They add: "Those investigating tight glycemic control should take a
step back and address the fundamental questions of defining quality
standards for tight glycemic control, finding affordable methods of
patronize and highly accurate measurement of blood glucose in the ICU,
and conduct multicenter efficacy studies to define if tighter
glycemic restraint can cut back mortality under optimal weather condition. If
tighter glycemic control tin be proved effective in optimal atmospheric condition,
determining how to get that benefit available to millions of
critically inauspicious patients in both developed and resource-poor countries
around the populace would be a unfeignedly worthwhile challenge. There is no
unsubdivided or clear answer to the complex problem of glycemic control in
critically ill adults; at pose, targeting tight glycemic control
cannot be said to be either right or wrong."
Benefits and Risks of Tight Glucose Control in Critically Ill
Adults: A Meta-analysis
Renda Soylemez Wiener; Daniel C. Wiener; Robin J. Larson
JAMA (2008). 300[8]:
pp. 933-944.
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Written by: Peter M Crosta
Copyright: Medical News Today
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Thursday, 4 September 2008
Thursday, 7 August 2008
Paolo Meneguzzi
Artist: Paolo Meneguzzi
Genre(s):
Latin
Other
Folk
Discography:
Musica
Year: 2007
Tracks: 12
Favola
Year: 2005
Tracks: 12
Lei ESanremo 2004
Year: 2004
Tracks: 18
Guardami Negli Occhi CDS
Year: 2004
Tracks: 4
Un Sueo Entre Las Manos
Year: 2001
Tracks: 12
Un Sogno Nelle Mani
Year: 2001
Tracks: 11
Emociones
Year: 1999
Tracks: 11
Paolo
Year: 1998
Tracks: 12
Por Amor
Year: 1997
Tracks: 10
Though he was born in Lugano, Switzerland, Paolo Meneguzzi grew up in the Milanese city of Varese. It was at that place that he low became interested in medicine, surrounded by a kinfolk to whom loose arts were important, receiving his kickoff gear guitar at historical period vIII from Decatur, and singing on tv set for the get-go time 2 geezerhood by and by. Though he wanted to perform in his native land, he decided he power hold more success in South America, and in 1996 he performed at Chile's Viña del Mar Festival, victorious it with the song dynasty "Aria Ariò." His debut album, Por Amor, was released in Chile the future year, followed by Paolo in 1998 and Emocion in 1999. After sign words to Ricordi, in 2001 Meneguzzi's Italian-language debut, Un Sogno Nelle Mani, came forbidden in short after his one-seventh place appearance at the annual San Remo Festival, and in 2003, Garland E', whose deed turn out was rumored to be just about his mother, was released, and went on to trade more than than cc,000 copies (it was reissued in a somewhat different interpreting the adjacent year as Coronal E' 2004), compulsive in the principal by the success of the individual "Guardami Negli Occhi (Prego)" at San Remo. Always fecund in the studio, Meneguzzi released Favola in 2005 and Musica in 2007, with, of class, comparable engagement at San Remo.
Friday, 27 June 2008
Junior Reid and The Bloods
Artist: Junior Reid and The Bloods
Genre(s):
Reggae
Discography:
Junior Reid and The Bloods
Year: 1995
Tracks: 10
Monday, 23 June 2008
Heroes Star Hayden Panettiere Launches Music Career
Hayden Panettiere, star of the television drama series Heroes, is to launch a music career.
The actress will release her debut single 'Wake Up Call' via digital-download this August, with an album expected in the opening months of 2009.
'Wake Up Call' was written by Andreas Rombhane and has been described as a “reggae-flavoured pop song”.
Rombhane, one of pop music's most established songwriters, has written songs for Geri Halliwell, Westlife and Diana Ross.
Panettiere's transition into music follows hot on the heels of Hollywood actress Scarlett Johansson, who released her debut album earlier this year.
In Heroes, Panettiere plays cheerleader Claire Bennett, who boasts the ability to rapidly self-heel.
Last month, Gigwise unveiled a gallery of actors who have moved into music. CLICK HERE to see who starred in the leading role.
See Also
Monday, 16 June 2008
Movie Reviews: The Happening
M. Night Shyamalan, the writer-director famous for ending his films with surprising twists has returned to the screen with The Happening.But those expecting to see his signature ending will likely be disappointed. As Elizabeth Weitzman writes in the New York Daily News."The big twist is that ... there's no twist at all. None. Zip. Nada." Several critics express disappointment that Shyamalan, after a series of blunders, has not made the kind of comeback they were hoping for. Claudia Puig in USA Today concludes her review by remarking, "Shyamalan's work has been deteriorating since the stir he caused in 1999 with The Sixth Sense. ... His last couple of movies --The Village and Lady in the Water -- have been particular disappointments, and The Happening continues the trend." Kyle Smith in the New York Post gives mostly two-word reviews for all of Shyamalan's movies since The Sixth Sense: "Stupid ending, stupid ending, stupid ending and, in a change of pace with his last film, Lady in the Water, stupid all the way through." Carina Chocano in the Los Angeles Times says that not all the blame should be laid at Shyamalan's feet. Costar Mark Wahlberg, she writes, gives "one of the worst performances of his career." But Manohla Dargis in the New York Times comments that the critics' knives were sharpened for Shyamalan even before the movie was screened for them. As for herself, she considers the film, "a divertingly goofy thriller with an animistic bent, moments of shivery and twitchy suspense and a solid lead performance from Mark Wahlberg." Likewise Glenn Whipp concludes in the Los Angeles Daily News that The Happening is "creepy, silly fun. And if it came from anyone else, it would be recognized as such. One thing is certain: The man hasn't lost his ability to entertain."
See Also
See Also
Tuesday, 3 June 2008
Fan pays €25,500 for Johansson date
A bidder on auction website eBay has paid $40,100 (€25,500) for a date with Scarlett Johansson.
The actress auctioned off a chance to be her guest at the premiere of her new film, 'He's Just Not That Into You', in aid of Oxfam.
Bidding for the date began at less than $1, but climbed to over $40,000 in just 10 days.
The winner, who is from the UK, will be brought to the event in a chauffeur-driven limousine to join the star on the red carpet. He or she can also bring a guest with them. After the screening, Johansson will hand her date a personal handwritten note.
However, it is unlikely any further romance will develop as the 23-year-old star is currently dating actor Ryan Reynolds.
The actress auctioned off a chance to be her guest at the premiere of her new film, 'He's Just Not That Into You', in aid of Oxfam.
Bidding for the date began at less than $1, but climbed to over $40,000 in just 10 days.
The winner, who is from the UK, will be brought to the event in a chauffeur-driven limousine to join the star on the red carpet. He or she can also bring a guest with them. After the screening, Johansson will hand her date a personal handwritten note.
However, it is unlikely any further romance will develop as the 23-year-old star is currently dating actor Ryan Reynolds.
Wednesday, 28 May 2008
Mystery Jets plan a murder at The Great Escape
Mystery Jets played a hugely energetic show last night (May 17) at the Honeyclub in Brighton at 9:15pm (BST). The gig was part of The Great Escape festival.
Fans packed out the venue to see the band, who turned the gig into an indie party, with the biggest dance moves and cheers saved for their hit 'Two Doors Down'. However, lighting problems caused the band to sarcastically request that the lighting man for the venue be killed.
The band came onstage to the sound of the menacing sirens of 'Hideaway', frontman Blaine Harrison asking the crowd, "Have you been enjoying The Great Escape? Good!"
After playing 'Half In Love With Elizabeth' the band politely asked whether the lighting in the venue could be sorted out. "Can someone please turn the lights on?", Harrison pleaded. "It's rather dark in here and we can�t see all these lovely people."
After playing 'Diamonds In The Dark', which got the crowd jumping excitedly, the band were still not impressed with the lighting on stage. Harrison made a further complaint: "OK, can someone please kill the lighting guy? Or maybe it�s a robot, in which case it would be much appreciated if someone fondled the robot."
Despite their complaints the band were in a good spirits. After playing the aforementioned 'Diamonds In The Dark' Harrison joked, "Did you like that song more than the first one then? No? Get out!" Then a woozy rendition of 'Flakes' led to the first crowd singalong of the night,
Despite playing live just down the road at the Sallis Benney Theatre an hour later than the Mystery Jets show, Laura Marling, who appears on the song on record, did not join the band onstage for 'Young Love'. The crowd were left ecstatic by the song's performance nonetheless.
Towards the end of the set, Mystery Jets invited the crowd to join them on a night out after the show. "We�re going down to Concorde 2 after this if anyone fancies joining us?" said Harrison. "We'll put every single person in this room on the guestlist. That's a joke, actually."
The frontman then asked the crowd for requests. The crowd almost unanimously shouted for latest single 'Two Doors Down'. The band obliged, leading to loud cheers and yet another singalong.
Mystery Jets played:
'Hideaway'
'Half In Love With Elizabeth'
'Diamonds In The Dark'
'Flakes'
'Hand Me Down'
'Young Love'
'Two Doors Down'
'Behind The Bunhouse'
May 28, 2008 at Forum, London -
More Mystery Jets tickets
Fans packed out the venue to see the band, who turned the gig into an indie party, with the biggest dance moves and cheers saved for their hit 'Two Doors Down'. However, lighting problems caused the band to sarcastically request that the lighting man for the venue be killed.
The band came onstage to the sound of the menacing sirens of 'Hideaway', frontman Blaine Harrison asking the crowd, "Have you been enjoying The Great Escape? Good!"
After playing 'Half In Love With Elizabeth' the band politely asked whether the lighting in the venue could be sorted out. "Can someone please turn the lights on?", Harrison pleaded. "It's rather dark in here and we can�t see all these lovely people."
After playing 'Diamonds In The Dark', which got the crowd jumping excitedly, the band were still not impressed with the lighting on stage. Harrison made a further complaint: "OK, can someone please kill the lighting guy? Or maybe it�s a robot, in which case it would be much appreciated if someone fondled the robot."
Despite their complaints the band were in a good spirits. After playing the aforementioned 'Diamonds In The Dark' Harrison joked, "Did you like that song more than the first one then? No? Get out!" Then a woozy rendition of 'Flakes' led to the first crowd singalong of the night,
Despite playing live just down the road at the Sallis Benney Theatre an hour later than the Mystery Jets show, Laura Marling, who appears on the song on record, did not join the band onstage for 'Young Love'. The crowd were left ecstatic by the song's performance nonetheless.
Towards the end of the set, Mystery Jets invited the crowd to join them on a night out after the show. "We�re going down to Concorde 2 after this if anyone fancies joining us?" said Harrison. "We'll put every single person in this room on the guestlist. That's a joke, actually."
The frontman then asked the crowd for requests. The crowd almost unanimously shouted for latest single 'Two Doors Down'. The band obliged, leading to loud cheers and yet another singalong.
Mystery Jets played:
'Hideaway'
'Half In Love With Elizabeth'
'Diamonds In The Dark'
'Flakes'
'Hand Me Down'
'Young Love'
'Two Doors Down'
'Behind The Bunhouse'
May 28, 2008 at Forum, London -
More Mystery Jets tickets
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